verb
1. To undeniably screw something up.
The intern at Fox News, who flubbed the banner line on this news report, is going to be looking for a new job soon.
Synonyms: addle, blunder, botch, bungle, confound, err, fail, goof, jumble, lapse, mistake, misconstrue, misinterpret, misjudge, mistake, miss, slip.

noun
1. The act or instance of such a colossal error.
The most embarrassing flub of the US media this year has been a Fox News banner line that read: "Obama bin Laden Dead."
Synonyms: aberration, befuddled, blooper, blunder, boo-boo, bungle, damn you auto correct, erratum, error, faux pas, gaffe, inaccuracy, lapse, miscalculation, misinterpretation, misjudgment, misstep, misprint, muddle, oops!, oversight, slip, slip up, snafu, solecism, trip, typo, typographical error, woopsy daisy.
* See Jenny Owen Youngs for more on relationships and flubbing up.